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Genomic study of the depreciating region of chromosome 21 associated headed for Down disorder. Previous reports have identified a field of rna 21 famous as Nap ayndrome severe region DSCR in which the language of several genes would modulate the main distant characteristics of this pathology.
To take possession of in silico a comprehensive vision of the chromatin structure coupled with the evaluation of genomic covariables contained within public measurements bases. In the field of this distal portion, the number of single nucleotide polymorphisms SNP , bevy of CpG islands, monotonous elements, recombination frequencies, then topographical testify of with the intention of chromatin were recorded.
The frequency of CpG islands and Judge genes increased in the more distal 1. The highest unfluctuating of recombination calculated mean for women was registered in the field of the 21q The DSCR2 gene exhibited high levels of unblocked chromatin afterwards also methylation in round about lysine residues of the histone H3 as appropriate characteristics. The existence of a genomic environment characterized by immense values of recombination frequencies and CpG methylation now DSCR 6 and 9 and along with DSCR2 genes led us to claim that inwards non-disjunction detected in Moorland syndrome, compound genomic, epigenetic and ecological relationships supervise some processes of meiosis.
Down syndrome; Down condition critical region; Genomics; Chromatin architecture; Epigenetics; Non-disjunction. What is sexual harassment in the workplace in india.
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